Author: Lian Stoeldraaijers, Eurocept Clinics, Podotherapie Valkenswaard. This case study was presented at the Diabetic Foot Congress 2025, Almelo, the Netherlands.
Patient introduction, recovery course prior to PLASOMA:
A 65-year-old male patient developed a non-healing ulcer on the plantar aspect of his right hallux (big toe), following a surgical procedure. Initial wound management occurred in a hospital setting. Two months later, the patient was seen at a specialized outpatient wound clinic, due to the persistent non-healing nature of the ulcer. A tissue culture showed an infection caused by Morganella morganii, an opportunistic Gram-negative rod. Further analysis found the bacteria to be an Extended-Spectrum Beta-Lactamase (ESBL) producer and multi-drug resistant (MDR), with no viable systemic antibiotic options. An initial treatment plan consisting of sharp debridement, topical gentamicin, and felt offloading was implemented.
After four weeks, the wound showed no signs of improvement. Because of the infection’s resistance profile, the patient’s comorbidities, and the failure of the conventional local treatment, adjunctive Cold Atmospheric Plasma (CAP) therapy was started using PLASOMA.
Results and frequency of PLASOMA cold plasma treatment:
• PLASOMA cold plasma treatment: twice a week, 7 treatments in total.
• A fully closed and dry wound in just over 5 weeks, indicating complete epithelialization.
Diabetes podiatrist Lian Stoeldraaijers, the wound care specialist involved in this case study:
“I see positive results with PLASOMA, even in people I didn’t expect to see it. One of the characteristics of cold plasma is that it kills microorganisms. PLASOMA cold plasma is applied to the wound in a very user-friendly process. I see it as a valuable addition to standard of care, especially for wounds that stagnate despite correct diagnosis and good wound care. The big advantage of PLASOMA is that it takes very little extra time and you don’t need to change your original treatment plan. You just add an extra step with PLASOMA after cleaning the wound.”
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